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Responses of G protein–coupled receptors (GPCRs) and nuclear hormone receptors (NHRs) trigger the stresses and pollutant-induced damage on Caenorhabditis elegans. In the germline, certain GPCRs (such as CED-1) and NHRs (such as NHR-12, NHR-14, NHR-47, and DAF-12) showed transgenerational response to pollutants, which mediated induction of transgenerational pollutant toxicity. Inhibition in germline CED-1 mediated transgenerational pollutant toxicity by causing transgenerational activation of MET-2 and SET-6. Change of germline NHRs expressions mediated transgenerational pollutant toxicity by resulting in transgenerational response of secreted ligands.

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Regulation of Transgenerational Toxicity by Germline G Protein–Coupled Receptors and Nuclear Hormone Receptors

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  • 发表日期：

    2026年

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  • Dayong Wang

摘要

Responses of G protein–coupled receptors (GPCRs) and nuclear hormone receptors (NHRs) trigger the stresses and pollutant-induced damage on Caenorhabditis elegans. In the germline, certain GPCRs (such as CED-1) and NHRs (such as NHR-12, NHR-14, NHR-47, and DAF-12) showed transgenerational response to pollutants, which mediated induction of transgenerational pollutant toxicity. Inhibition in germline CED-1 mediated transgenerational pollutant toxicity by causing transgenerational activation of MET-2 and SET-6. Change of germline NHRs expressions mediated transgenerational pollutant toxicity by resulting in transgenerational response of secreted ligands.