Scholarlink

Neurotransmitters are important chemical messengers to transduce the neuronal information. Exposure to pollutants could induce transgenerational response of certain neurotransmitters. Accompanied with this, transgenerational response of genes regulating neurotransmitter synthesis, such as germline tbh-1 governing octopamine synthesis, was induced by pollutant exposure. Inhibition in germline TBH-1 functioned together with change of octopamine receptors of SER-6 and OCTR-1 in the offspring to regulate transgenerational pollutant toxicity by causing transgenerational inhibition in SER-6 and transgenerational activation of OCTR-1. In the germline, nuclear hormone receptor DAF-12 acted as upregulator for TBH-1 to regulate transgenerational pollutant toxicity. In the intestine, ELT-2 was identified as target of SER-6 an OCTR-1 to regulate transgenerational pollutant toxicity.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Neurotransmitter Signals

  • 章节

  • 发表日期：

    2026年

查看全文
  • Dayong Wang

摘要

Neurotransmitters are important chemical messengers to transduce the neuronal information. Exposure to pollutants could induce transgenerational response of certain neurotransmitters. Accompanied with this, transgenerational response of genes regulating neurotransmitter synthesis, such as germline tbh-1 governing octopamine synthesis, was induced by pollutant exposure. Inhibition in germline TBH-1 functioned together with change of octopamine receptors of SER-6 and OCTR-1 in the offspring to regulate transgenerational pollutant toxicity by causing transgenerational inhibition in SER-6 and transgenerational activation of OCTR-1. In the germline, nuclear hormone receptor DAF-12 acted as upregulator for TBH-1 to regulate transgenerational pollutant toxicity. In the intestine, ELT-2 was identified as target of SER-6 an OCTR-1 to regulate transgenerational pollutant toxicity.