Scholarlink

In Caenorhabditis elegans, exposure to pollutants induced transgenerational activation of germline Ephrin ligand EFN-3 and Ephrin receptor VAB-1. Activation of germline EFN-3 mediated transgenerational pollutant toxicity by causing VAB-1 activation in the offspring. During control of transgenerational pollutant toxicity, KSR-1/2, CED-1, SET-6, nuclear hormone receptors, and RAB-5 were identified as upregulators for germline EFN-3. VAB-1 functions in germline and neurons to regulate transgenerational pollutant toxicity. During control of transgenerational pollutants toxicity, NDK-1 and LIN-23 were identified as targets of germline VAB-1, and DBL-1, JNK-1, MPK-1, and GLB-10 were identified as targets of neuronal VAB-1.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Ephrin Signals

  • 章节

  • 发表日期：

    2026年

查看全文
  • Dayong Wang

摘要

In Caenorhabditis elegans, exposure to pollutants induced transgenerational activation of germline Ephrin ligand EFN-3 and Ephrin receptor VAB-1. Activation of germline EFN-3 mediated transgenerational pollutant toxicity by causing VAB-1 activation in the offspring. During control of transgenerational pollutant toxicity, KSR-1/2, CED-1, SET-6, nuclear hormone receptors, and RAB-5 were identified as upregulators for germline EFN-3. VAB-1 functions in germline and neurons to regulate transgenerational pollutant toxicity. During control of transgenerational pollutants toxicity, NDK-1 and LIN-23 were identified as targets of germline VAB-1, and DBL-1, JNK-1, MPK-1, and GLB-10 were identified as targets of neuronal VAB-1.