Ethno-botany and Ethno-pharmacology of Indravaruni: An Important Medicinal Plant of Tribal Culture and Its Action Against SARS-CoV-2

The SARS-CoV-2 or COVID-19 pandemic witnessed from late 2019 to 2021tested health-care structures, creating the infection a global pandemic that led to a community healthiness emergency. Other comorbidities such as pneumonia, diabetes, stress, asthma, etc. developed hastily as a major comorbidity for SARS-CoV-2severity, accumulating the risk of undesirable results if one got sick with the SARS-CoV-2 virus. The SARS-CoV-2pandemic has encouraged wide spread investigation into prospective treatments, including the study of natural products as repurposing medications. They have high assistance, with diverse biological activity, and exceptional variety. This brief review proposes to highlight the active properties of the plants Indravaruni or Citrulluscolocynthis (L.) Schrad and its metabolites that are recognized to offer healing aids against cancer, leprosy, diabetes, jaundice, bronchitis, asthma, etc., and can be cast as possible adjuvant treatment in severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 infection. Determining the knowledge of the phyto constituents which have various medical properties and may reveal anti-viral effects when put to use, such that it can help in infection prevention. The medicinal plants consist of numerous secondary metabolites and potent ethno-pharmacological shreds of evidence, the chosen medicinal plant constitutes several active secondary metabolites, which are extensively used by Ayurvedic practitioners to treat a wide number of diseases. Herein, we give those active secondary metabolites that were used with the help of molecular docking to understand their fit affinity with the Coronavirus-2019-nCoV- protein (6VWW). The described literature was obtained from PubMed, Science Direct, Google Scholar, Web of Science, Scopus, Clinical Trials.gov, and Wiley online library with a focus on peer-reviewed English-language publications that exclusively addressed different types of diseases and SARS-CoV-2collaboration, clinical implications, and the healing treatments of traditional medicine with natural products. Indravaruni or Citrullus colocynthis (L.) Schrad has a variety of ethnomedicinal and ethnopharmacological uses against cancer, bronchitis, asthma, etc. which may also be used for the COVID-19 virus and its strains.