Carcinoma Pancreas

Tumors in the pancreatic head often present early with obstructive jaundice, while those in the neck and central body tend to present later and have a poorer prognosis. New-onset diabetes or unexplained, unintended weight loss should raise clinical suspicion and prompt further investigation. A contrast-enhanced CT scan (CECT) of the abdomen and pelvis is the preferred initial investigation for diagnosis and staging; MRCP is useful for cystic lesions, and FDG-PET-CT is suited for high-risk metastatic disease. Management depends on the stage of the disease (resectable, borderline resectable, locally advanced, or metastatic), with complete surgical resection offering the best chance of cure for resectable cases.