Wheat production is increasingly constrained by waterlogging, particularly in regions characterized by heavy soils, unpredictable rainfall, and insufficient drainage, all of which impair normal root function. This chapter provides a comprehensive overview of scientific and technological advancements that have transformed strategies for managing waterlogging stress in wheat. It reviews progress from traditional field practices, such as raised beds and surface drainage, to recent discoveries regarding physiological responses, including root aerenchyma formation, metabolic adaptation to hypoxia, and enhanced antioxidant defences. Advances in breeding, facilitated by transcriptomic profiling, genomic technologies, and molecular markers, have improved the identification of tolerant genotypes and the incorporation of key traits. Innovative approaches, including CRISPR-based genome editing, high-throughput phenotyping, remote sensing, and artificial intelligence-driven advisory systems, further support early detection and adaptive management. Biological interventions, such as microbial inoculants and seed priming, confer additional resilience during critical growth stages. However, significant challenges persist due to limited genetic diversity, climate variability, and socioeconomic barriers to technology adoption. This chapter emphasizes the strategic actions required to develop climate-resilient wheat production systems capable of withstanding future waterlogging stress.