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Biomedical films utilizing biopolymers for tissue engineering scaffolds, must provide high mechanical strength, swelling capacity, and biocompatibility to effectively mimic the natural extracellular matrix. This study synthesized ultrasound-assisted chitosan–alginate films using a Box-Behnken Design to evaluate the effects of varying polymer ratios, CaCl2 concentrations, and sonication durations. A 40 kHz ultrasound treatment was employed to enhance particle interaction and emulsification. The optimal formulation, consisting of a 50:50 chitosan–alginate ratio immersed in 1.2 M CaCl2 and processed under 60 min of sonication, exhibited a superior tensile strength of 30.09 MPa, an elongation at break of 8.81%, and a swelling ratio of 70.97%, These properties specifically meet the rigorous mechanical requirements for cartilage scaffolds. Structural analyses via FTIR, SEM, and DSC–TGA (STA) confirmed the formation of a dense, crack-free polyelectrolyte complex with enhanced thermal stability. These results demonstrate that ultrasound-assisted synthesis significantly outperforms traditional blending methods, establishing these films as highly suitable candidates for cartilage regeneration and related biomedical applications.

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Synthesis and Characterization of an Ultrasound-Assisted Chitosan–Alginate Biomedical Film for Tissue Engineering Scaffolds

  • 会议论文

  • 发表日期：

    2026年

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  • Rohgewyl Ivonne A. Alabado,
  • Justine Denise S. Cruz,
  • Cedrick Israel T. Del Rio,
  • Beatrice A. Fernandez,
  • Aubrey Palapuz,
  • Jerry G. Olay,
  • Rugi Vicente Rubi

摘要

Biomedical films utilizing biopolymers for tissue engineering scaffolds, must provide high mechanical strength, swelling capacity, and biocompatibility to effectively mimic the natural extracellular matrix. This study synthesized ultrasound-assisted chitosan–alginate films using a Box-Behnken Design to evaluate the effects of varying polymer ratios, CaCl2 concentrations, and sonication durations. A 40 kHz ultrasound treatment was employed to enhance particle interaction and emulsification. The optimal formulation, consisting of a 50:50 chitosan–alginate ratio immersed in 1.2 M CaCl2 and processed under 60 min of sonication, exhibited a superior tensile strength of 30.09 MPa, an elongation at break of 8.81%, and a swelling ratio of 70.97%, These properties specifically meet the rigorous mechanical requirements for cartilage scaffolds. Structural analyses via FTIR, SEM, and DSC–TGA (STA) confirmed the formation of a dense, crack-free polyelectrolyte complex with enhanced thermal stability. These results demonstrate that ultrasound-assisted synthesis significantly outperforms traditional blending methods, establishing these films as highly suitable candidates for cartilage regeneration and related biomedical applications.