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High mortality and morbidity are continually increasing due to drug-resistant TB strains, which have become a global health issue. There is a very low success rate in treating XDR/MDR-TB strains, which is very low in comparison to the wide range of drug-resistant strains. The WHO expects that by 2025, TB-mediated health issues will have been reduced by 95%. Multiple clinical investigations suggested that the usage of preexisting drugs (drug repositioning) is a valuable option to reduce health-related issues induced by XDR/MDR-TB strains. Technological advancement further adds to the rapidity in the search for novel repurposed drugs against XDR/MDR-TB strains. Here, we discuss repurposed drugs, as well as their efficacy against drug-resistant and drug-susceptible TB strains, and the use of repurposed drugs with a combination of anti-TB drugs.

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Drug Repositioning: An Alternative Strategy to Tackle Multidrug-Resistant M. tuberculosis

  • 章节

  • 发表日期：

    2026年

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  • Divakar Sharma,
  • Indu Singh,
  • Indira Kumari Verma,
  • Arun Ratn,
  • Deepa Bisht,
  • Jasbir Dalal,
  • Megh Singh Dhakad

摘要

High mortality and morbidity are continually increasing due to drug-resistant TB strains, which have become a global health issue. There is a very low success rate in treating XDR/MDR-TB strains, which is very low in comparison to the wide range of drug-resistant strains. The WHO expects that by 2025, TB-mediated health issues will have been reduced by 95%. Multiple clinical investigations suggested that the usage of preexisting drugs (drug repositioning) is a valuable option to reduce health-related issues induced by XDR/MDR-TB strains. Technological advancement further adds to the rapidity in the search for novel repurposed drugs against XDR/MDR-TB strains. Here, we discuss repurposed drugs, as well as their efficacy against drug-resistant and drug-susceptible TB strains, and the use of repurposed drugs with a combination of anti-TB drugs.