High-entropy alloys (HEAs), a class of metallic materials composed of five or more principal elements in near-equiatomic ratios, have emerged as a transformative paradigm in alloy design. Unlike conventional alloys based on one or two principal elements, HEAs derive their unique mechanical behavior from high configurational entropy, severe lattice distortion, sluggish diffusion, and cocktail effects. This chapter provides a comprehensive overview of the mechanical properties of HEAs, encompassing strength, ductility, and hardness. The influence of key microstructural features such as phase composition, grain size, dislocation behavior, and precipitation on mechanical performance is examined. The chapter concludes with future directions for the development of high-performance HEAs with tailored mechanical properties through compositional and microstructural engineering.