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Bacillus subtilis spore surface display technology is a versatile tool for heterologous protein display on the B. subtilis spores. This innovative platform has been utilized in various biotechnological fields such as biocatalysts and as antigen-carriers in vaccine formulations. In addition, the B. subtilis surface display system is pivotal in sustainable energy and environmental applications, including bioremediation, waste treatment, and the development of biosensors. This chapter provides an overview of the advancements in this technology and its applications. The main drawbacks of this technology and avenues for future research are also discussed.

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Bacillus subtilis Spores as a Robust Platform for Surface Display: Applications in Vaccines Development, Whole-Cell Biocatalysts, and Environmental Biotechnology

  • 章节

  • 发表日期：

    2026年

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  • Howra Bahrulolum,
  • Seyede Nafise Tabatabaei,
  • Parisa Beyranvand,
  • Sina Ekhlasi,
  • Gholamreza Ahmadian

摘要

Bacillus subtilis spore surface display technology is a versatile tool for heterologous protein display on the B. subtilis spores. This innovative platform has been utilized in various biotechnological fields such as biocatalysts and as antigen-carriers in vaccine formulations. In addition, the B. subtilis surface display system is pivotal in sustainable energy and environmental applications, including bioremediation, waste treatment, and the development of biosensors. This chapter provides an overview of the advancements in this technology and its applications. The main drawbacks of this technology and avenues for future research are also discussed.