Genetic Basis of Cardiac Arrhythmia

The familial nature of cardiac anomalies and arrhythmia has been recognized for decades as an important cause of motility and morbidity in children; however, the high cost for genetic studies along with delay of results has been a limiting factor for its clinical use. Recent advances in genetic linkage analysis, cloning, and rapid sequencing revealed important new informations on arrhythmia associated with disease-causing genetic mutations. Further, the ability to perform whole-exome sequencing (WES) and whole-genome sequencing (WGS) led now to a better understanding of inherited arrhythmia and ultimately to new clinical applications with a relatively low cost.