Often, in our popular discourse around science skepticism, we are quick to dismiss those who are suspicious of science or science-based policies as being obviously irrational, confused, or dangerous. This ignores the wide variety of ways that one might be worried about science and its associated incursions into our lives. This chapter aims to give the reader a sense of the diverse ways that one might be suspicious of science. It tracks some of the trouble we have describing members of skeptical groups, particularly in the cases of those who are skeptical about the causal connection between HIV and AIDS, and those who are worried about vaccine safety. It then looks at groups whose skepticism takes the form of wanting more science to be done, rather than skepticism about science as a good route to knowledge about health and disease. This can take the form of either calling for more research to be done on specific diseases or on particular types of bodies. Finally, the chapter looks at skepticism that has nothing to do with the science itself, but is rather directed at science-based policy or clinic-level implementation of policy.