The individual situation of people with chronic illnesses is determined by various framework and contextual factors. The concept of salutogenesis offers preventive approaches to counteract a progressive course and recurrences. Furthermore, psychosocial contextual factors, stressors, and risk factors can be positively influenced by resilience and coping, among others. Based on shared knowledge and goals, as well as an active engagement with resources, a sense of coherence can develop, enabling professionals to provide supportive health-promoting interventions for those affected.