Functioning biobanks are a crucial basis and thus a prerequisite for targeted research and development work in personalized medicine. In this context, an optimal quality of tissue and/or liquid samples such as blood, cerebrospinal fluid, and urine is an absolutely necessary prerequisite for being able to match the biological material available with the corresponding clinical data of the patient. The sum of all available research data and their reliability is an essential part of a high-quality, accredited biobank operation and thus for the high value of the biobank samples and their biodata for clinical and preclinical studies. In contrast, the loss of sample material and its biodata, as well as incoherent results after repeated analyses of biobank samples, represents a relevant problem for existing biobanks worldwide. In this chapter, innovative perspectives for future biobank developments are presented and discussed. In addition, a concept for a so-called next-generation biobank is presented, as it is already being implemented at many university and industrial research sites in Germany, Austria, and Switzerland.