Inflammatory rheumatic diseases have musculoskeletal symptoms such as pain, swelling, and functional limitations of the joints, spine, muscles, tendon insertions, and tendon sheaths as their main symptoms. As autoimmune systemic diseases, they also affect blood vessels (vasculitides) and can also manifest in the skin, eyes, nervous system, and almost all internal organs. Cardiac involvement is common when rheumatic patients are systematically examined with sensitive techniques such as Echocardiography, CT or MRI examinations or autopsy findings are used. Clinically manifest heart manifestations are, however, rarer, but can indicate a serious inflammatory systemic disease even in young people as the first symptom and be the reason for aggressive immunosuppressive therapies. Laboratory markers of systemic inflammation are almost always elevated; specific autoantibodies (rheumatoid factor, antinuclear antibodies, etc.) help to classify the disease.