A 2-Year-Old Toddler with Painful Bluish-Livid Discolorations of the Hands and Feet

The young child with bluish discolored hands and feet, along with other family members affected by this symptomatology: This is the typical case constellation for the disease picture of Chilblain Lupus, which belongs to the Interferonopathies and is very clearly to be distinguished from benign childhood acrocyanosis. Interferonopathies can be treated today with specific active substances, such as JAK inhibitors, hence a rapid differential diagnosis is crucial.