Machine learning (ML) offers high potential in manufacturing industry; moreover, for example the effectiveness of quality prediction and evaluation can be greatly improved using Machine learning, which can generate significant competitive advantages. However, the potentials of ML are not fully exploited by small and medium-sized enterprises. A qualitative empirical study was conducted with 60 companies from different industry sectors to determine when SMEs are more likely to use ML. Here, it is shown that the willingness to invest in applications is substantial for the implementation of ML. Also, the availability of sufficient qualitative data within the SME is imperative for applying ML. Furthermore, recommendations for action for SMEs are established to close the technology adoption gap in SMEs and to leverage the benefits of ML.