In energy transition hydrogen is – in addition to electrical energy – a second energetic pillar and therefore another option for the mobility sector. Beside the consumer, a fuel cell or an internal combustion engine, the safe storage and provision of the hydrogen by a tank system plays a crucial role. In addition to various positive properties, handling hydrogen also entails some challenges: It has a very small molecular structure, is odorless and highly flammable and can cause explosive reactions. Consequently, suitable safety concepts must be developed for hydrogen tank systems. The approach for the development of such concepts is described in this paper: From screening of relevant regulations, norms and standards, extraction of requirements, the derivation of additional safety goals from risk considerations up to functional implementation in a control unit to electrical integration into the target vehicle with final tests to prove its functionality. Since large amounts of energy need to be stored for heavy duty applications, multi tank systems are common. The second part of the paper therefore provides an overview of the special features and challenges of multi tank systems discussed regarding spatial, system-architectural and thermodynamical aspects.