Occupant and partner protection aims to minimize or prevent the consequences of road accidents for occupants of different vehicle types, including passenger cars, commercial vehicles, and two-wheelers. Beyond vehicle occupants, this also includes road users outside the vehicle interior. These individuals are referred to as vulnerable road users (VRUs). The development of protection concepts for vehicle occupants and VRU is a challenging technology field, as it requires the networking of different disciplines: The holistic view of traffic events, the analysis of accident root causes, the course of the accident, the possibilities for detecting an accident event, and the development of intervention strategies are examples of development tasks in occupant and partner protection. This chapter describes how protection concepts of integral safety for motor vehicles can be realized by linking the systems and components of passive safety with other domains. Examples of this are interventions by restraint systems already in the pre-crash phase or the fusion of sensors from different vehicle domains for differentiating intervention strategies and extended adaptability functions of restraint systems. The core of this chapter is the presentation of the technologies of restraint systems, especially seat belt systems and airbag systems. They make a significant contribution to reducing injury risks—especially for vehicle occupants. They are supplemented by child restraint systems and technologies for occupant protection for further vehicle segments beyond passenger cars.