Reluctantly abandoning my career in rock-and-roll and inspired by the elegant mathematics of reconstruction in computed tomography I started working in medical imaging as a clinical scientist. Working in the clinical environment I appreciated how much in medicine was unknown. I became convinced that a physics and engineering approach could contribute to improving healthcare and that this must be done in close collaboration with clinical colleagues in order to be relevant. I also became convinced that real impact in healthcare engineering would only come about by working closely with industry. Only this would enable wide dissemination.