Stringent environmental and noise standards in the automotive sector, as well as customer expectations, are pushing the limits of classic noise and vibration mitigation solutions. In the search of novel vibro-acoustic solutions, locally resonant metamaterials come to the fore as they promise to combine a light weight with excellent vibro-acoustic properties, at least in dedicated target frequency regions. In this publication, a metamaterial solution is applied to a vehicle to reduce the interior structure-borne noise due to the acoustic tyre resonances around 220 Hz. This metal 3D printed novel solution is applied on the rear wheel arches of a vehicle and serves as an alternative for dynamic damper solutions that are typically installed in line with the suspension on the vehicle body. Numerical and experimental analyses show how 3D printed resonant metamaterials can be a performant lightweight alternative to the common noise and vibration solutions used in the automotive sector.