Discussion
摘要
In this study, SARP-driven expression of BGCs of a selected number of genome-sequenced actinomycetes strains was successfully achieved. Overexpression of PapR2 resulted in increased production of bioactive compounds which were assessed with bioassays against different test strains including bacteria and fungi. Thus, it was verified that the targeted SARP-driven activation strategy is a valuable method to be applied to unlock the genetic potential of actinomycetes to produce novel natural products.