Results
摘要
The aim of the work was to activate antibiotic biosynthetic gene cluster expression of prioritized genome-sequenced actinomycetes with the help of SARP-type regulators. PapR2 is a SARP-type regulator and pathway-specific activator of pristinamycin biosynthesis in S. pristinaespiralis. To achieve biosynthetic gene cluster activation with the help of PapR2, suitable overexpression constructs are a prerequisite.