The need for efficient delivery methods that maintain and enhance the bioactivity of phytocomplexes derived from plants has been highlighted by the growing demand for functional foods. Synergistic assemblies of bioactive substances, including polyphenols, flavonoids, terpenoids, and alkaloids, known as phytocomplexes, provide a variety of health advantages, such as anti-inflammatory, neuroprotective, cardioprotective, and antioxidant properties. However, when added directly to food matrices, their low oral bioavailability, instability, and poor solubility limit their effectiveness. Phytosomes, in particular, are liposome-based encapsulation systems that have become cutting-edge tools for overcoming these obstacles. These nanostructures, which are made of biocompatible phospholipid bilayers, improve gastrointestinal absorption, enable controlled release, and shield bioactive substances from deterioration. Stability and targeted delivery are further enhanced by sophisticated designs such as coated liposomes and nutriosomes (liposomes with outer layers based on dextrin). The functional improvements of liposome structures are thoroughly covered in this chapter, along with the advantages and design reasoning behind each. A major step toward next-generation nutraceuticals, the incorporation of liposomal nanotechnology into food science allows for the creation of products that are supported by science, palatable to consumers, and beneficial to health.