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When roasting coffee, up to 40% of the coffee silverskin (CSS) gets lost as waste. The aim of this chapter is the identification of alkaloid extracts from CSS and the evaluation of their antioxidant, antihemolytic, and alpha-amylase inhibitory activities. Alkaloids were extracted using two polar solvents in an acidic medium (methanol solvent and methanol/water solvent). Two fractions were obtained: total alkaloids of methanol extracts (E1) and total alkaloids of hydro-methanol extracts (E2). The results indicated that the E2 fraction presented the strongest antioxidant potential in terms of parameters like (DPPH IC50 = 1.57 ± 0.282 μg/ml) and the most inhibitory activity on alpha-amylase (IC50 = 0.66 ± 0.268 mg/ml). Nevertheless, the E1 fraction exhibited the most significant antihemolytic activity (HT50min = 0.72 ± 0.2 mg/ml). These activities were largely attributed to an enhancement of the alkaloid constituents detected by GC-MS. These alkaloids consist of methylxanthine, pyridine/pyrrolidine, and quinoline. The alkaloids found in CSS may have potential applications in the pharmaceuticals and food industries.

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Coffee Silverskin Waste as an Alternative to Produce Alkaloids with Antioxidant, Antihemolytic, and Alpha-Amylase Inhibitory Activities

  • 动态工具书词条

  • 发表日期：

    2025年

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  • Habi Salim,
  • Cherrak Sabri Ahmed,
  • Mokhtari-Soulimane Nassima,
  • Bekhti Sari Fadia,
  • Souna Mimoun,
  • Hafida Merzouk

摘要

When roasting coffee, up to 40% of the coffee silverskin (CSS) gets lost as waste. The aim of this chapter is the identification of alkaloid extracts from CSS and the evaluation of their antioxidant, antihemolytic, and alpha-amylase inhibitory activities. Alkaloids were extracted using two polar solvents in an acidic medium (methanol solvent and methanol/water solvent). Two fractions were obtained: total alkaloids of methanol extracts (E1) and total alkaloids of hydro-methanol extracts (E2). The results indicated that the E2 fraction presented the strongest antioxidant potential in terms of parameters like (DPPH IC50 = 1.57 ± 0.282 μg/ml) and the most inhibitory activity on alpha-amylase (IC50 = 0.66 ± 0.268 mg/ml). Nevertheless, the E1 fraction exhibited the most significant antihemolytic activity (HT50min = 0.72 ± 0.2 mg/ml). These activities were largely attributed to an enhancement of the alkaloid constituents detected by GC-MS. These alkaloids consist of methylxanthine, pyridine/pyrrolidine, and quinoline. The alkaloids found in CSS may have potential applications in the pharmaceuticals and food industries.