Linalool, linalyl acetate, limonene, carvone, trans-anethole, isopinocamphone, and α- and β-thujones are compounds that determine the quality of coriander, lavandin, caraway, aniseed, hyssop, and sage essential oils. Numerous studies indicate that the genetic factor is crucial in the synthesis of these volatile compounds in essential oils. However, biotic and abiotic factors can significantly affect the change their synthesis. Some of these factors are regulated by agrotechnics, such as sowing/planting time, sowing rate, fertilization, irrigation, weed control, and harvest time. However, the impact of climate change has been so pronounced in recent years that it has led to the shifting of the cultivation areas of some plants. In this chapter, the results of three-years investigations in Serbia on six essential-oil bearing plants are presented. The moderately continental climate with elements of the subtropical climate, which has been evident in the last few years, is very favorable for the cultivation of aniseed, coriander, lavandin, and hyssop, while it is unfavorable for the cultivation of annual caraway and sage.