Rotors syndrome (AKA rotor-type hyperbilirubinemia) is an autosomal recessive disorder. It is a rare cause of mixed direct and indirect hyperbilirubinemia. The disease is distinguished by nonhemolytic jaundice because of a chronic increase of chiefly conjugated bilirubin. This occurrence results from hepatocellular disability to deposit conjugated bilirubin which leads to leakage into plasma, causing hyperbilirubinemia. Its present symptom is jaundice, although Rotor syndrome is a benign and self-limiting disorder that does not require treatment. Typically, patients are asymptomatic, and jaundice is usually an unexpected finding. Regarding symptoms, it is similar to Dubin-Johnson syndrome; nevertheless, the liver shows normal histology.

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Rotor Syndrome

  • Niloofar Deravi,
  • Nima Rezaei

摘要

Rotors syndrome (AKA rotor-type hyperbilirubinemia) is an autosomal recessive disorder. It is a rare cause of mixed direct and indirect hyperbilirubinemia. The disease is distinguished by nonhemolytic jaundice because of a chronic increase of chiefly conjugated bilirubin. This occurrence results from hepatocellular disability to deposit conjugated bilirubin which leads to leakage into plasma, causing hyperbilirubinemia. Its present symptom is jaundice, although Rotor syndrome is a benign and self-limiting disorder that does not require treatment. Typically, patients are asymptomatic, and jaundice is usually an unexpected finding. Regarding symptoms, it is similar to Dubin-Johnson syndrome; nevertheless, the liver shows normal histology.