In 1996, Thomas et al. described a family with the clinical features of what would later be recognized as hereditary mixed polyposis syndrome, but this term was formally introduced by Whitelaw et al. in 1977 who further characterized the condition as a distinct clinical entry (Whitelaw et al. 1997). Thomas et al. observed that individuals with HMPS may be prone to inflammatory and metaplastic polyps. Older patients often had colorectal cancer, while younger, screened individuals typically showed benign polyps characteristic of the syndrome (Thomas et al. 1996). Hereditary mixed polyposis syndrome (HMPS) is an inherited syndrome affecting the large intestine, characterized by a combination of hyperplastic, atypical juvenile, and adenomatous polyps, which can significantly raise the risk of colorectal cancer if not treated properly (Fig. 1) (Murday and Slack 1989; Thomas et al. 1996). Symptoms of this syndrome can begin to manifest during childhood (Whitelaw et al. 1997).