Dermatological problems of athletes are a result of mechanical trauma, cutaneous infections, contact dermatitis, and environmental exposures. Preexisting dermatoses can be aggravated by continued physical skin contact, environmental factors, anabolic steroid and supplement use, and persistent sweating in athletes. Detailed history and physical examination are important in differentiating skin pathologies arising from participation in athletics from other skin conditions, both banal and serious (e.g., verrucae vulgaris, subungual malignant melanoma, Osler’s nodes, and Janeway lesions of endocarditis). Athletes are more prone to mechanical trauma, infection, and contact dermatitis due to the use of occlusive clothing, excessive sweating, frequent skin-to-skin contact, and communal use of equipment and facilities. Recognition, treatment, and prevention of sports-related skin diseases will maximize the athlete’s performance and general well-being.