Principally, beekeepers are at high risk for the development of immediate-type allergy to bee venom; sensitization prevalence is in the range of 30–60%. In some cases, IgE-mediated allergy was reported against honey, pollens, royal jelly, mold fungi, and bee body allergens. Occupational skin diseases are reported only in single beekeepers. Important contact allergens are propolis, beeswax, royal jelly, and essential oils. Potential irritants are chemicals used for the treatment of bee infections with parasitic mites and mold fungi.