Electroporation induces a rapid increase in cell membrane permeability, altering membrane conductivity and subsequently influencing the measured impedance of cell suspensions or tissues. This indicates that impedance measurements can be used to perform a real-time assessment of the electroporation phenomenon in a minimally invasive fashion. However, impedance measurements in biological organisms depend on many factors and processes besides membrane permeabilization. This lack of specificity can be a significant drawback when using impedance measurements as an indicator of electroporation. This chapter provides a brief overview of the information that can be judiciously extracted from impedance measurements during and after the application of electroporation pulses. An equivalent electrical model of cell suspensions and tissues is commonly employed to better understand how the different processes occurring during electroporation can affect the measured impedance of a sample. These measurements, widely used to observe and analyze the dynamics of the electroporation phenomenon, have the potential to be used as a tool for assessing the effectiveness of electroporation treatments. A significant conclusion from the experimental studies on the topic is that conductivity measured shortly after treatment appears to be correlated with electroporation effectiveness in terms of cell membrane permeabilization. Thus, it has the potential to serve as an indicator of electroporation effectiveness. On the other hand, dynamic conductivity during the electroporation pulses, which is much easier to measure, does not appear to correlate with electroporation effectiveness.