The most common reasons for long-term antiplatelet therapy include preventing and treating ischemic cardiovascular and cerebrovascular diseases, as well as peripheral arterial disease. Low-dose aspirin, clopidogrel, ticlopidine, and dipyridamole are the most frequently used antiplatelet agents. Due to their different mechanisms of action, dual antiplatelet therapy may be recommended in certain clinical situations, such as after percutaneous coronary intervention with stent placement, typically involving a combination of aspirin and clopidogrel. In patients on antiplatelet therapy, there is a risk of increased and extended bleeding after oral surgical procedures, including tooth extraction; therefore, caution is necessary. This chapter outlines dental considerations for patients on single and dual antiplatelet therapy.