Pelvic organ prolapse refers to the descent of one or more of the genital organs below their normal position. Pelvic organ prolapse may be asymptomatic or may cause a variety of symptoms including bulge, urinary, bowel, or sexual symptoms. Management of pelvic organ prolapse aims at improving quality of life and is guided by patients’ symptoms. In this chapter, we review causes, evaluation, and management of pelvic organ prolapse.