A Unified Disease Theory, even if incomplete, would revolutionize medical thinking and practice. To re-evaluate Life, especially its States, assigning additional importance to non-cellular and immaterial issues, such as hierarchy, communication, interdependence, exchanges of information and matter and control may be needed. The independently procreating life units exist either individually or in collectives of different levels and principles of organization but usual adaptations include defining roles, assigning tasks and transforming to suit functionality prerogatives. Such collectives show variable tolerance to dissimilar or alien units and appears in a number of forms due to evolution. Tissues, organs and multicellular organisms are further evolutions of the same pattern in more evolved and dedicated, eukaryotic cells, with more elaborate means for communication, coordination and differentiation. And the top state is the different communities, of communicating and coordinately functioning, but not necessarily synchronously living, individuals, separated in spatial terms but relevant and associated in temporal terms. Whether this relevance is also functional and allows consideration of such collectives as (meta)organisms rather than perceiving them as societies/communities is vital for understanding but also for responding to challenges posed to different aspects of health by such entities, ranging from infections to tumors.