The Disruptive Biosecurity is meant to tackle the Total Biothreat, but also more elaborate schemes that amplify the Total Biothreat to Meta-Biothreat status. The Disruptive Biosecurity has to be adaptable to respond to the sum of possible, not just probable, threats. These include: conventional bioevents perpetrated by conventional or not bioagents; the agentless events, where standard biosecurity concepts, means and methods and Medical Countermeasures are irrelevant; the cyber-amplified and -engineered bioevents, where biovigilance might have blind spots, despite the implication of real, live bioagents; the massive, surge outbreaks, simultaneous or successive might these be, which may overload response, exhaust personnel, wear equipment and deplete resources. Although response, bioresillience and biodefense were invented, deployed and to some degree still operating without AI, the latter is a toolkit that might unlock performance levels and capabilities essential for response adaptation and preparation for the infinite number and variety of threat scenaria. It may sort, assess, promote and support in planning, operational, logistics and cognitive terms different modes, levels and commodities for biosecurity, including surveillance, diagnostics, protection, prophylaxis and therapeutic amenities. Moreover, its use for Biosecurity might be the sole antidote to balance its use by prospective, AI-legible bio-offenders.