The Meta-Biothreat is not a matter of technologic superiority or miracle-performing means, although these help a lot. But the focus is on the transfer, adaptation and creative use of technology and methodologies developed elsewhere, in other fields, for other purposes, constantly adapting and adjusting assets and means and morphing the milestones for the long-term objectives. The innovative and imaginative use of existing, available and not necessarily high-quality or high-performance means at the perpetrators’ disposal in order to maximize effects and achieve objectives is at the center of the Meta-Biothreat, while the AI, although not necessary, may assist in two distinct ways: as an enabler and as a direct or indirect effector. The latter case includes minimally perpetrated bioevents, such as agentless ones, or cyber-enabled and cyber-leveraged ones, which include active bioagents the impact of which is achieved or maximized by—usually cyber-assistance. The former case revolves around different kinds and aspects of logistics, including human resources, materiel and abstract/immaterial assets. The tainting, corruption, spiking or otherwise compromise of bioamenities or the malicious use of valid ones might be a key risk area, as would be the Psychological Operations regarding the prestige and social/international standing of target and alleged perpetrator.