Technology has offered considerable options and an impressive and multilevel array of means to create, enhance and upkeep biosecurity during the last quarter-century. The diagnostics, such as Molecular/genomic analysis and scanning methods, with the Nucleic Acid Amplification Tests being in the forefront, or the Serodiagnostics that now come regularly in solid formats as Rapid Diagnostic Tests but also improvements in Microscopy and culturing through the advent of Culturomics are undeniably the mainstays of this progress. Similarly explosive advances refer to all the issues incorporating Bioinformatics and remote applications, such as lab and diagnostic automations, electronic health files and their fast turnover and dispatch, remote examination and test analysis. Moreover, intervention by therapeutic means seems also to be evolving despite the scarcity of new antibiotics. New micro- and macromolecular antimicrobial compounds of biological origin and whole organisms such as bacteria and viruses/phages, along with advanced and controllable delivery methods are coming online for normal medicinal use and may be adopted, adapted and modified for Biosecurity use. However, most of these modalities regard the biothreats as simply a perpetrated case of a natural epidemic or, rather outbreak, and are thus susceptible to perpetrators' suppressive or deceptive countermeasures.