A complex interplay between climate change, air pollution, and human health has emerged as a global issue of high priority. Pollutants such as particulate matter, ozone, sulfur dioxide, nitrogen dioxide, and volatile organic compounds- key precursors of photochemical smog- are primarily generated by transportation and industry as well as biomass burning. These pollutant species pose significant local health risks and contribute to global climate change by altering atmospheric chemistry and intensifying the greenhouse effect. Against the backdrop of shifting temperature and precipitation patterns, air pollution may further exacerbate health risks, leading to increased incidences of respiratory and cardiovascular diseases, infectious illnesses, and premature mortality. This chapter presents a comprehensive overview of the interconnections between climate dynamics and air quality, and how their interaction impacts public health. The review will serve as a baseline study of recent research methods and results on the health outcomes of temperature variations as a result of climate change and their effects on air quality.