The decline in crop yields linked to soil vulnerability by water erosion is an obstacle to food security in the North of Côte d'Ivoire. Therefore, the objective of this study is to characterize the level of soil vulnerability, based on remote sensing and GIS in the Sub-Prefecture of Tioroniaradougou, in the North of Côte d'Ivoire. A qualitative methodological approach made it possible to determine the explanatory parameters of soil vulnerability. This approach was based on the establishment of single-factor maps from remote sensing and Geographic Information Systems (GIS), integrating multi-source data such as soil erodibility, altitude, slope, and land use. The establishment of single-factor maps made it possible to obtain a multi-factor vulnerability map, thus making it possible to characterize the explanatory factors of soil degradation. The results reveal that the Tioroniaradougou Sub-Prefecture is influenced by three (3) vulnerability zones: low vulnerability zones (19.89%) of the total area, medium vulnerability zones (35.43%) and high vulnerability zones (44.68%). The validation of the multifactorial map and that of land use required a field visit. This verification presented two levels of concordance, 83.33% for the good concordance rate and 16.67% for the non-concordance rate. The production of the multifactorial vulnerability map is a decision-making tool for land development in urban or natural environments.