Majority of food crops are glycophytes, which do not flourish in saline environment; hence, soil salinity poses a significant threat to world food security. An important abiotic factor that stunts plant development and yield is salinity stress, which hinders vital biochemical and physiological processes and causes an overabundance of reactive oxygen species (ROS), which in turn cause oxidative damage to cellular components. Moreover, to mitigate ROS, signalling molecules including hydrogen sulphide (H2S) and nitric oxide (NO) are essential in regulating antioxidant defence mechanisms and improving stress resilience in plants. Recent studies indicate the essential significance of nitric oxide in eliciting adaptation responses in plants under saline conditions. NO plays a critical role in the active engagement of ABA-mediated stomatal control. Comparable interactions of NO with other phytohormones, including gibberellins (GAs), auxins (IAAs), ethylene (ET), cytokinins (CKs), brassinosteroids (BRs), and salicylic acid (SA), were also noted. Furthermore, we examine the absence of interaction with other gaseous signalling molecules, including ROS and reactive sulphur species (RSS). We delve into the significance of NO and its complex signalling with phytohormones in plants subjected to salt stress, considering NO’s active involvement in plant physiology and its interaction with different metabolic pathways.