While Irreversible Electroporation (IRE) shows promise for treating various tumors, its clinical application isn’t yet widespread, and human data remain relatively limited. To advance and optimize IRE for breast tumor therapy, a C++-based computer model of single-cell electroporation was developed on the RadStudio 11 platform. This software includes a graphical interface for diverse cell simulations, with OpenGL used to visualize unit cell pore formation, ensuring high-fidelity representation. The results will be crucial for determining the optimal IRE parameters for breast tissue within an in-silico simulator and will be validated to ensure the computer models’ reliability and accuracy in simulating real conditions.

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Development and Implementation of a Single-Cell Electroporation Simulator

  • Kristina Bliznakova,
  • Zhivko Bliznakov,
  • Nikolay Dukov,
  • Georgi Todorov,
  • Todorka Dimitrova

摘要

While Irreversible Electroporation (IRE) shows promise for treating various tumors, its clinical application isn’t yet widespread, and human data remain relatively limited. To advance and optimize IRE for breast tumor therapy, a C++-based computer model of single-cell electroporation was developed on the RadStudio 11 platform. This software includes a graphical interface for diverse cell simulations, with OpenGL used to visualize unit cell pore formation, ensuring high-fidelity representation. The results will be crucial for determining the optimal IRE parameters for breast tissue within an in-silico simulator and will be validated to ensure the computer models’ reliability and accuracy in simulating real conditions.