Hope plays a central role in the experience of individuals facing chronic, progressive, and life-limiting illnesses, particularly in palliative care. As a multidimensional concept, hope influences emotional, psychological, spiritual, and relational well-being, contributing significantly to the ability to cope with the situation and to quality of life. This narrative review aims to identify, describe, and analyze the main instruments used to assess hope and spirituality, with a special focus on tools validated for European Portuguese. A bibliographic search was conducted in the main health databases, resulting in 34 initial records, of which 11 met the inclusion criteria. The instruments identified include the Beck Hopelessness Scale, the Adult Hope Scale, the Herth Hope Scale, and the Herth Hope Index, as well as their validated versions in Portuguese. In addition, five spirituality assessment instruments were examined, highlighting the close relationship between spiritual well-being and hope. The results underscore the relevance of standardized assessment tools to guide holistic, person-centered interventions in palliative care. The availability of validated instruments in Portugal represents a significant step toward evidence-based practice and the promotion of hope as a therapeutic resource.