Preterm birth <37 weeks is the leading cause of neonatal death. While the majority of cases are of unknown causes, women with known risk factors can be appropriately monitored and managed to reduce risk. Interventions such as cervical cerclage have been used since the 1950s to reduce the risk of preterm birth. In this chapter, you will gain a basic understanding of the use of cervical cerclage, its indications, and its evidence base in different subgroups.