As part of this chapter, we explore how large datasets (often referred to as “big data”) and artificial intelligence (AI) are revolutionizing the field of medicine and how increasingly important a role they will play within the specific context of perinatal care. As we stand on the threshold of a new era in healthcare, driven by technological innovation, this chapter aims to provide a comprehensive exploration of how these advancements are shaping perinatal medicine, enhancing outcomes for mothers and their newborns, and introducing new paradigms in obstetrics.