Durability of 3D printing cement-based construction still needs to be investigated. On one hand, the large amount of paste phase, the low w/c ratio of printable mortars and the high exposed surface of 3D printed specimens to environmental conditions, due to the absence of formworks, lead to high early age shrinkage and cracking risk. On the other hand, poor bonding between 3DP layers can produce cold joints that could compromise 3D printed members’ strength and durability. This study investigates the adaptability of self-healing strategies for 3DP cement-based construction requirements. A lime-cement binder, 1:1 volumetric ratio, was designed to generate autogenous self-healing capacity. Besides, cellulose microfibres (CMF) were added to increase tensile strength, restraining crack size. Then, a Superabsorbent Polymer (SAP) was used to provide water retention capacity, acting as an internal curing agent, in order to reduce early age shrinkage. Mortars’ printability was assessed by rheology and extrudability tests. Mixtures’ buildability was evaluated by fresh compression tests and by monitoring early age hydration with ultrasonic non-destructive techniques. A robotic-arm 3D printer was used to produce lab scale specimens for a comprehensive evaluation of the printing process. The conclusions of this study could shed light on the design of low-cement-content mortars with self-healing capacity for 3D Printing applications.