In this chapter, the focus is on the requirements for designing effective, gender-responsive climate policies in Latin America. A transdisciplinary framework is adopted, bringing together political ecology, intersectional feminism and development studies, in order to critique the epistemic colonialism embedded in prevailing institutional frameworks. Through the analysis of ten national cases—Argentina, Belize, Bolivia, Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador and Guatemala—the chapter reveals how these policies perpetuate narratives that marginalise the knowledge of indigenous peoples and women, exacerbating intersectional vulnerabilities through extractivism and gender exclusion. Set against a backdrop of structural inequalities and global commitments such as the Paris Agreement, the analysis proposes theoretical models that link epistemological critique with transformative practice. It emphasises the pivotal role of women as epistemic agents in crafting inclusive policies, thereby positioning the region as a reference point for decolonial sustainability in the Anthropocene.