In this paper, the use of radiofrequency (RF) signals in the ISM band offers new opportunities for noninvasive biomedical applications. This work presents the application design and analysis of a monitoring and control system for muscle thermal stimulation, using directed and controlled RF energy transmission for temperatures between 35 and 40  \(^\circ \) C. The main objective is to develop a platform through a mobile application that allows the generation of localized thermal stimulation in muscle tissue by means of RF signals, integrating electromyographic activity (EMG) and temperature sensors, with real-time response capacity. The methodology contemplates the use of an ESP32 microcontroller as the core of the system, connected to an AD8232 EMG sensor to detect muscle activity and adjust the intensity of the RF signal according to physiological demand. Power modulation and control techniques are employed on the signal from 4 to 13.56 MHz, ensuring compliance with electromagnetic exposure standards. The preliminary simulation and prototype test results show adequate heat generation in simulated tissue, correlated with measured muscle activity. The inclusion of EMG as feedback allows for adaptive and safe thermal stimulation. The proposed system is concluded to be feasible, cost-effective and highly versatile for future applications in muscle rehabilitation, physiotherapy, and other fields.