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The extracellular matrix (ECM) is a complex mesh of collagen, fibronectin, laminins, elastin, proteoglycans and glycoproteins that regulate the biochemical and biophysical properties of the cellular microenvironment. Integrin-mediated adhesion of cells to the ECM is an essential regulator of membrane trafficking and anchorage-dependent signalling regulating cell shape, spreading, division and migration. Integrin-matrix interaction also contributes to cellular mechanosensing. This allows changing matrix organisation (2D vs. 3D) and stiffness to influence cell function. The known roles of organelles (Golgi, mitochondria, endoplasmic reticulum (ER)) in cell function and the growing understanding of how the ECM, through adhesion, could regulate their function will be discussed. The role this could have in cellular mechanosensing in 2D vs. 3D microenvironments will also be addressed. The scope such a regulatory crosstalk could have in regulating organelle and cell function makes it particularly interesting to study.

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ECM-Mediated Regulation of Organelles and Their Function

  • 章节

  • 发表日期：

    2026年

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  • Radhika Malaviya,
  • Vaishnavi Raut,
  • Debasmita Mazumdar,
  • Tushar Sherkhane,
  • Arnav Saha,
  • Aadishakti Dalai,
  • Nagaraj Balasubramanian

摘要

The extracellular matrix (ECM) is a complex mesh of collagen, fibronectin, laminins, elastin, proteoglycans and glycoproteins that regulate the biochemical and biophysical properties of the cellular microenvironment. Integrin-mediated adhesion of cells to the ECM is an essential regulator of membrane trafficking and anchorage-dependent signalling regulating cell shape, spreading, division and migration. Integrin-matrix interaction also contributes to cellular mechanosensing. This allows changing matrix organisation (2D vs. 3D) and stiffness to influence cell function. The known roles of organelles (Golgi, mitochondria, endoplasmic reticulum (ER)) in cell function and the growing understanding of how the ECM, through adhesion, could regulate their function will be discussed. The role this could have in cellular mechanosensing in 2D vs. 3D microenvironments will also be addressed. The scope such a regulatory crosstalk could have in regulating organelle and cell function makes it particularly interesting to study.