Combination oral contraceptive pills (COCs) have been available in the United States for over 50 years and are the most common single form of contraception used by US women. Up to 79.8% of women who have ever been sexually active have used COCs, and 14% of reproductive-age women who use contraception report current COC use. Combined oral contraceptive pills have two hormonal components, an estrogen and a progestin. COCs are considered second-tier contraceptives due to their typical use failure rate of 7%. COCs have many noncontraceptive benefits and may be used by some women to improve menstrual patterns, lessen dysmenorrhea, or ameliorate acne.