Current generations are living through a historical event in virology: the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2SARS-CoV-2) pandemicpandemic. If you asked people when the last major pandemic was, many would probably say the Spanish flu of 1918–1920. Pandemics happen more frequently than most people think (Sampath et al., Cureus 13:e18136–18144, 2021). There have been at least five recorded pandemics between the Spanish flu and the recent SARS-CoV-2 pandemic. While the SARS-CoV-2 pandemic has brought with it indescribable sorrow and pain, it has also increased people’s awareness of the impact viruses can have on life on Earth. Terms such as hygiene, modes of infection, community spread, quarantine, vaccines, etc. have become part of our daily conversations. As this book’s first chapter provided a basic review of proteomic technologies for virologists, this chapter provides a basic review of virology for proteomic scientists. While virologist may find this chapter unsatisfying, hopefully proteomic scientists will learn enough to be able to understand how proteomic technology can be used to further detail the structure, function, and life cycle of viruses. This chapter will provide both generic and specific examples of viral structures, how they infect cells, and their effects on both the infected cell and the entire organism.